Weekly doses of taxol prolonged lives of breast cancer. It is a cancer chemotherapy drug that works by slowing or stopping cancer cell growth. Taxol is a type of chemotherapy extracted originally from the pacific yew tree taxotere is a synthetic drug that works similarly. Pazdur r1, kudelka ap, kavanagh jj, cohen pr, raber. Taxol paclitaxel is a drug used in the treatment of nonsmall cell lung cancer. Because i was getting painful neuropathy in my hands and feet, my doctor decided to switch my chemo regimen half way through.
Cisplatin vs paclitaxel for triple neg the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. This study found that women diagnosed with hormonereceptorpositive. Noting how little information was available on docetaxel side effects, the fdas oncologic drugs advisory committee unanimously recommended denying sanofis approval application. Both are given every 34 weeks but taxol is given every week fashion too. I did round one six scheduled cycles of taxol and carboplatin with no incident. Rabertt department of gastrointestinal oncology and digestive diseases, tdepartment of breast and gynecologic medical oncology, epartment of medical specialities, ttdepartment of clinical. In addition, some advanced pancreatic cancer patients may be treated with taxol infusions.
This emedtv article briefly discusses the potential benefits of taxotere and provides a link to more information on this type of chemotherapy. If you have breast cancer or nonsmall cell lung cancer, your healthcare provider may recommend taxotere. Taxotere is a newer chemotherapy agent that kills cancer cells in a similar manner. Docetaxel is approved to be used alone or with other drugs to treat breast cancer that is locally advanced or has metastasized spread to other parts of the body and has not gotten better with other chemotherapy. Reversible marrow suppression was the major doselimiting toxicity of taxotere see warnings and precautions. A dose of 100 mgm 2 in patients previously treated with chemotherapy was associated with increased hematologic toxicity, infection, and. The older chemotherapy agent produced by bristolmyers squibb has been one of the most widely used drugs in the adjuvant treatment of breast cancer since. Paclitaxel and docetaxel are the two presently clinically available representatives of. Of course, many cancer patients seek treatment options that promise the best longterm, diseasefree survival rates. Hang in there you will soon be done and on your way to. I went for round two today and after 1 hour of premeds 10 minutes into the taxol i pitched forward, got very hot all over, had diffuculty breathing, got an extremely bad metal taste in my mouth much worse than the one from. Obviously both have side effects, but the 18 week course of taxotere and carboplatin is what i had with.
Taxol was bad i was completelyutterly exhausted the entire time. Taxotere understanding the chemotherapy drug docetaxel. Taxol paclitaxel remove taxol from your drug comparison. A cycle of treatment comprises of an hour premedication, and a 1hour infusion of taxotere followed by a 30minute infusion of carboplatin. Difference between taxol and taxotere doctor answers. Multiple longterm studies have proven that there is no statistical difference in survival rates between taxol and taxotere for the treatment of breast cancer that has spread to the lymph nodes or presents the risk of spreading. Taxotere and taxol are two taxanes, a group of chemotherapy agents used to treat advanced or metastatic breast cancer in patients that did not respond to prior therapies.
Docetaxel and paclitaxel comparing the two taxanes. This medication is used to treat cancer such as breast, lung, prostate, stomach, and headneck cancer. Both are used in treatment of many cancers breast, lung, ovary, headneck, stomach, esophageal, prostate, etc. Taxanes interfere with the ability of cancer cells to divide. She experienced severe body pain but painkillers were able to fix that.
Taxotere docetaxel remove taxotere from your drug comparison. Lowdose weekly administration of this chemotherapy is less toxic but as effective as the dosedense option for women with highrisk breast cancer. Taxol for the treatment of nonsmall cell lung cancer. I chose to do the 12 weekly taxol as dr said it was the most aggressive plan and i was going to do everything that was possible to do. The taxotere is often given if you have an allergic reaction to taxol.
But the federal agency was worried about taxoteres incredibly high toxicity. Primarily prescribed to treat breast, lung as well as ovarian cancers, taxol belongs to the taxane drug class along with taxotere. A semisynthetic form of taxol is the anticancer compound taxotere, a patented taxol analogue that has a tertbutoxycarbonyl group instead of the benzoyl group on the taxol side cahin and a hydroxyl group instead of the acetoyl group on the taxol b ring. The median time to nadir was 7 days, while the median duration of severe neutropenia taxotere. From what i understand taxotere is very similarto taxol except it was developed because many people experienced neuropathy from the taxol. It is also used with doxorubicin hydrochloride and cyclophosphamide to treat breast cancer that is node. Litigation over the cancer drug taxotere is popping up all over the country. So far, ill still keep my every three weeks carbo schedule.
Approximately onehalf of patients had received prior chemotherapy for metastatic disease, and onehalf entered the study following relapse after adjuvant therapy. Read the patient information leaflet available from your pharmacist before you start using paclitaxel. Taxotere is used to treat breast cancer, nonsmall cell lung cancer, advanced stomach cancer, head and neck cancer as well as metastatic prostate cancer. Chicago breast cancer patients obtained the same disease control with less toxicity when they received weekly lowdose chemotherapy instead of a. Taxotere is an intravenous injection manufactured by sanofiaventis.
A generic version of docetaxel, manufactured by hospira, was approved in 2011. The drug is manufactured by sanofi, a french multinational pharmaceutical corporation. Taxol is an anticancer antineoplastic or cytotoxic chemotherapy drug. Taxotere is a chemotherapy drug used for the treatment of breast cancer. According to studies, taxotere showed more benefits to survival than taxol paclitaxel, another chemotherapy drug in the same class. For me taxol caused me to have neuropathy, and altered my tastebuds. Taxol asked by banditwalker on saturday, november 23, 20 ac vs. About a decade ago, a study showed that adding taxol to standard chemo reduced the risk of breast cancer recurrence. Compare carboplatin vs cytoxan comprehensive analysis by.
Taxotere i had taxol two years ago and yes i lost my eyelashes and eyebrows and suffered terrible bone pain for about 2 days after each treatment and i developed mouth sores which made eating certain foods difficult. Taxal is paclitaxel, toxotere is docetaxel classified as plant alkaloids, have similar properties, commonly used in breast cancer, small cell lung cancer, met prostate cancer ge junction gastric cancers. Sometimes it is not safe to use certain medications at the same time. Sanofi brought taxotere to the fda in 1994, two years before taxol was approved. Although hair loss is very common with many chemotherapy agents used to treat breast cancer, permanent hair loss should not occur. For treatment after failure of prior platinumbased chemotherapy, taxotere was evaluated as monotherapy, and the recommended dose is 75 mgm 2 administered intravenously over 1 hour every 3 weeks. But due to loss of appetite and not drinking enough fluids, she had low bp due to which they ended up giving her fluid ivy twice. The drug was subsequently approved in the united states, with the standard of care being four doses once every three weeks. Compare abraxane vs taxol headtohead with other drugs for uses, ratings, cost, side effects, interactions and more. Paclitaxel and docetaxel share a similar mechanism of action. Fda label information for this drug is available at dailymed. Prescribed for breast cancer adjuvant, breast cancer metastatic, breast cancer, kaposis sarcoma, nonsmall cell lung cancer, ovarian cancer, wilms tumor.
Taxotere usually is given in combination with other chemotherapy medicines and is used after surgery to treat. The taxol would be taken weekly for 12 weeks as opposed to the ac which would be 1 time every three weeks for 12 weeks. Both paclitaxel taxol and docetaxel taxotere are highly effective at treating breast cancer, and both work by attacking the skeletons of cells, preventing them from dividing. Docetaxel is an antineoplastic chemotherapy drug, used to inhibit or stop the development of cancerous tumors. These drugs are administered via an infusion drip into a vein through a small and very thin plastic tube called a cannula.
Taxotere is classified as a cytotoxic drug, which is a drug that stops rapidly dividing cells. Taxol chemotherapy, side effects for nonsmall cell lung. One study that analyzed the effects of taxotere found that up to 9. It is usually given over 2 hours every 3 weeks, as an outpatient. The effects of taxoids taxol and taxotere were followed on two human cancerous cell lines bladder carcinoma j82 cells and epidermoid carcinoma kb 31 cells. The taxoids, paclitaxel taxol and docetaxel taxotere, represent a novel class of antineoplastic drugs. The other taxane, taxotere docetaxel is more potent than taxol. These results suggest a more favorable benefittorisk ratio for docetaxel compared to paclitaxel when these drugs are used as single agents or in combination. It is given via intravenous infusion, sometimes in combination with other chemo drugs. Information regarding the differences between the chemotherapy drugs docetaxel taxotere and paclitaxel taxol used in the treatment of breast cancer.
During the debate over taxotere vs taxol, oncologists may. Docetaxel is a member of a family of drugs called taxanes. This ed material has been downloaded from a licensed data provider and is not for distribution, except. Taxotere is a much more potent drug than taxol, meaning that the same effect can be achieved with lower a dose. Docetaxel is usually administered as a 1h infusion every 3weeks15. Selected from data included with permission and ed by first databank, inc. I had a reaction to taxol and they changed me to taxotere. Listing a study does not mean it has been evaluated by the u. Cisplatin vs paclitaxel for triple neg full text view. Paclitaxel is used to treat various types of cancer. Abraxane is a novel paclitaxel formulation, which does not containcremophorel16,17. Taxol paclitaxel taxotere docetaxel has been vastly advertised by its manufacturer sanofiaventis, as a newer, more effective alternative to taxol paclitaxel. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
The amount of taxol and the schedule that it is given will receive depend on many factors, including your height and weight, your. Instead of a large dose of taxotere along with a side of carboplatin every three weeks, i am now getting a smaller dose of taxol weekly. Onc has given us three options to chose from for the next round 1continue with lower dosage of taxotere every. Ituseshumanserumalbumin to encapsulate hydrophobic paclitaxel molecules in particles of around nm 18. Taxol paclitaxel dosing, indications, interactions.
The immunopharmacology of paclitaxel taxol, docetaxel taxotere. Adriamycin is hard on the heart and supposedly has more side effects. One of the big differences in the taxol and taxotere is the solution the drug is prepared in. Nab paclitaxel nanoparticule albuminbound paclitaxel nab paclitaxel. Taxol has been used extensively in the treatment of breast cancer. The clinical development of paclitaxel was initially hampered by hypersensitivity reactions hsrs. What other drugs will affect paclitaxel onxol, taxol. Taxotere is taxol suspended in a solution that minimizes those side effects. Paclitaxel taxol and docetaxel taxotere are among the most unique, and successful, chemotherapeutic agents used for the treatment of breast and ovarian. No i never had pain or nausea with either ac or taxol could not sleep without pills, lived on the couch or bed for all 12 of them.
Nabrinsky on difference between taxol and taxotere. Taxol weekly better than every three weeks for breast cancer. If you have any questions, consult your doctor or pharmacist. The good news is that the administration time is 1 hour as compared to the 3. How taxol chemotherapy is given and possible side effects. Chemoqueen i found the website but no reference to your trial. Researchers from canada conducted a clinical trial to compare taxotere to taxol in the treatment of patients with metastatic breast cancer. Doctors give trusted answers on uses, effects, sideeffects, and cautions.